Our group collaborates closely with the Catalan Institute of Oncology (ICO) and is actively involved in two major research programs: ProCURE (ICO) (ProCURE Oncology) and CARE (IGTP) (CARE Program). The team is led by Dr. Eva Martinez-Balibrea, a renowned expert with over 20 years of experience in the field (Publications).

PROJECT OVERVIEW:

We have recently secured funding from the Spanish Ministry of Science, Innovation, and Universities for the KRAS-RESIST project, which investigates resistance mechanisms to mutated KRAS inhibitors in mCRC. The project includes the generation of drug-resistant cell lines and genomic and transcriptomic analyses to identify tumour vulnerabilities, aiming to discover combination therapies and novel biomarkers for treatment selection.

MAIN RESPONSIBILITIES

• Conduct bioinformatics analyses of omics data from the KRAS-RESIST project and other sources.
• Develop and implement computational approaches to gain insights into cancer biology.
• Collaborate with interdisciplinary teams and contribute to high-impact research publications.

QUALIFICATIONS AND EXPERIENCIE

Candidates must meet the eligibility criteria for MSCA Postdoctoral Fellowships 2025 (HORIZON-MSCA-2025-PF-01):

• Hold a Ph.D. in Biomedicine, Bioinformatics, or a related field, preferably with a focus on cancer research.
• Have a maximum of 8 years of full-time equivalent research experience since obtaining the Ph.D.
• Must not have resided or worked in Spain for more than 12 months in the 3 years prior to the application deadline (10-09-2025).
• Strong track record of research achievements, including at least two first-author publications in Q1 journals.
• Expertise in bioinformatics, with experience in handling and interpreting multi-omics data.
• Ability to extract biological insights from complex datasets; experience in cancer immunity studies is highly valued.
• Fluency in English (written and spoken).

WHAT WE OFFER

• The selected candidate will be incorporated upon obtaining an MSCA-PF-2024 or similar fellowship.
• Flexible payment (childminding vouchers).
• 23 days holiday and 5 days for personal matters +2 days for Easter + 2 days for Christmas .
• Training capsules by the company.
• Be part of an excellent multidisciplinary research centre with the HRS4R badge.
• Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

HOW TO APPLY

Interested persons must attach to the application:

• Motivation letter explaining their interest in the position.
• Updated CV.
• Contact of 2-3 references.

Applications will be evaluated in accordance with the guiding principles and objectives of the supply systems, following the process described below:

1. Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.
2. Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.

Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.

DEADLINE FOR APPLICATIONS

• The deadline for the next MSCA Postdoctoral Fellowships call is September 10, 2025.
• Expression of interest should be submitted before April 1, 2025.
• Proposals will undergo internal evaluation, and candidates will be informed of the results.

More info and application: https://igtp.jobs.personio.com/job/1968427?language=en&display=en

As part of the National Plan for Recovery and Resilience (Piano Nazionale di Ripresa e Resilienza, PNRR), IRCCS Istituto Clinico Humanitas has started the public selection procedures for recruitment under the projects regarding the Enhancement and strengthening of biomedical research in the NHS.

TITLE AND BRIEF PROJECT DESCRIPTION:

Uncovering novel targets and pathways to enhance the efficacy of combination immunotherapy for lung cancer KMN309-CUP: E23C24000220006

Immunotherapies with immune checkpoint inhibitors (ICIs) have revolutionized the treatment of solid tumors, including lung cancer. Combining ICIs with conventional chemotherapy has proved successful, but only in a subset of patients. Despite ICIs reinvigorate dysfunctional T cells against the cancer, acquired resistance occurs due to additional suppressive mechanisms, e.g., alternative checkpoints, inhibitory cell populations and insufficient inflammation, among others. However, knowledge in this regard is limited due to the absence of longitudinal patient specimens. We will take advantage of a unique collection of primary and metastatic tumors before and after ICI, and use omics technologies to unravel the complex relationships between the immune system, the stroma and the tumor in resistant patients. We aim to discover major cellular and molecular mechanisms of resistance that will be further mined in preclinical models of lung cancer to enhance tumor regression.

JOB PROFILE AND BRIEF DESCRIPTION OF ACTIVITIES REQUIRED:

Postdoctoral Scientist to join the Cellular and Molecular Oncoimmunology Group led by Dr. Eduardo Bonavita.  For more information, visit Eduardo Bonavita Group.

The successful candidate will be responsible of:

• Pursuing the program of work agreed with the Group Leader.
• Designing and executing experiments.
• Establishing procedures and developing new approaches; acquiring new skills.
• Maintaining accurate records of experiments and reagents.
• Preparing and presenting work at and attending weekly laboratory meetings.

Qualifications required: PhD in immunology, cancer biology, or related fields.

Technical skills:

• Solid background in immunology and familiarity with cellular and molecular biology, biochemistry, and standard mouse work.
• Experience in immune profiling of cancer samples.

Preferred candidate choice requirements:

• Familiarity with mouse cancer models, single-cell RNA sequencing, spatial transcriptomics, flow cytometry, tissue culture, and data analysis.
• Highly motivated, detail-oriented, organized, flexible, and a team player.
• Excellent written and spoken English.
• Collaborate effectively with colleagues.
• Learn and apply new skills.
• Engage in constructive debate and support lab objectives.
• Maintain a safe and compliant working environment.

Humanitas on the basis of the profiles received, will activate in the terms indicated, the screening process by inviting suitable candidates to participate in the interviews of selection, after verification of the cv and qualifications, which will be held in presence or in call.

The recruitment board, will be composed by the Project Manager and the Human Resources Department, will be responsible for the overall evaluation and cv received and will give feedback to the candidates within 60 days of the first interview.

Open Position (published): 24/10/2023 until 22/12/2023

All candidate data collected from the application shall be processed in accordance with applicable law: Dlgs 198/2006 e dei Dlgs 215/2003 e 216/2003;  privacy ex artt. 13 e 14 del Reg. UE 2016/679.

Please help us to make this program a success by forwarding this email to possible interested candidates. Detailed information concerning the application and selection process can be found on the program’s website: www.carrerasleaders.eu. The key points are:

• Scientific scope: blood cancers
• Collaborative projects ideally with research stays at international and intersectoral partners.
• International mobility of candidates

Eligible candidates should have up to 7 years of postdoctoral experience and comply with the MSCA mobility rule of not having resided or carried out their main activities (work, study, etc.) in Spain for more than 12 months in the last 3 years immediately prior to the Call deadline.

For your perusal and further dissemination of the Call, find the Programme brochure and its social media handles:

Email: carrerasleaders@carrerasresearch.org
Twitter: @CarrerasLeaders
Instagram: @carrerasleaders
Website: www.carrerasleaders.eu
Programme Brochure: download here