Job title: Postdoctoral Scientist- Cellular and Molecular Oncoimmunology
As part of the National Plan for Recovery and Resilience (Piano Nazionale di Ripresa e Resilienza, PNRR), IRCCS Istituto Clinico Humanitas has started the public selection procedures for recruitment under the projects regarding the Enhancement and strengthening of biomedical research in the NHS.
TITLE AND BRIEF PROJECT DESCRIPTION:
Uncovering novel targets and pathways to enhance the efficacy of combination immunotherapy for lung cancer KMN309-CUP: E23C24000220006
Immunotherapies with immune checkpoint inhibitors (ICIs) have revolutionized the treatment of solid tumors, including lung cancer. Combining ICIs with conventional chemotherapy has proved successful, but only in a subset of patients. Despite ICIs reinvigorate dysfunctional T cells against the cancer, acquired resistance occurs due to additional suppressive mechanisms, e.g., alternative checkpoints, inhibitory cell populations and insufficient inflammation, among others. However, knowledge in this regard is limited due to the absence of longitudinal patient specimens. We will take advantage of a unique collection of primary and metastatic tumors before and after ICI, and use omics technologies to unravel the complex relationships between the immune system, the stroma and the tumor in resistant patients. We aim to discover major cellular and molecular mechanisms of resistance that will be further mined in preclinical models of lung cancer to enhance tumor regression.
JOB PROFILE AND BRIEF DESCRIPTION OF ACTIVITIES REQUIRED:
Postdoctoral Scientist to join the Cellular and Molecular Oncoimmunology Group led by Dr. Eduardo Bonavita. For more information, visit Eduardo Bonavita Group.
The successful candidate will be responsible of:
- Pursuing the program of work agreed with the Group Leader.
- Designing and executing experiments.
- Establishing procedures and developing new approaches; acquiring new skills.
- Maintaining accurate records of experiments and reagents.
- Preparing and presenting work at and attending weekly laboratory meetings.
Qualifications required: PhD in immunology, cancer biology, or related fields.
Technical skills:
- Solid background in immunology and familiarity with cellular and molecular biology, biochemistry, and standard mouse work.
- Experience in immune profiling of cancer samples.
Preferred candidate choice requirements:
- Familiarity with mouse cancer models, single-cell RNA sequencing, spatial transcriptomics, flow cytometry, tissue culture, and data analysis.
- Highly motivated, detail-oriented, organized, flexible, and a team player.
- Excellent written and spoken English.
- Collaborate effectively with colleagues.
- Learn and apply new skills.
- Engage in constructive debate and support lab objectives.
- Maintain a safe and compliant working environment.
Humanitas on the basis of the profiles received, will activate in the terms indicated, the screening process by inviting suitable candidates to participate in the interviews of selection, after verification of the cv and qualifications, which will be held in presence or in call.
The recruitment board, will be composed by the Project Manager and the Human Resources Department, will be responsible for the overall evaluation and cv received and will give feedback to the candidates within 60 days of the first interview.
Open Position (published): 24/10/2023 until 22/12/2023
All candidate data collected from the application shall be processed in accordance with applicable law: Dlgs 198/2006 e dei Dlgs 215/2003 e 216/2003; privacy ex artt. 13 e 14 del Reg. UE 2016/679.
